【个人简介】

张继辉

职称：教授，研究员，副主任医师

职务：副院长

邮箱：zhangjihui@gzhmu.edu.cn

工作经历：

2023.03-至今：4188云顶集团附属脑科医院 副院长，教授/研究员/副主任医师

2022.06-2023.03：4188云顶集团附属脑科医院 教授/研究员/副主任医师

2020.05-2022.05：广东省人民医院精神卫生中心 研究员

2015.10-2020.04：香港中文大学精神科学系 助理教授

2012.12-2015.09：香港中文大学精神科学系 研究助理教授

2010.11-2012.11：美国国立卫生研究院精神卫生研究所 博士后

2010.08-2010.10：香港中文大学精神科学系 研究助理

【研究方向】

精神病与精神卫生学；睡眠医学

【科研项目】

1.课题名称：昼夜节律调控睡眠稳态的神经环路机制及临床干预策略（联合申请B）

资助单位：国家自然科学基金专项项目（睡眠及睡眠障碍的机制与干预新策略研究专项）

基金号：82341240

资助金额:150万元

资助期限：2024.01-2026.12

2.课题名称：基于数字化多模态评估的失眠障碍亚型识别与精准治疗方案开发验证

资助单位：国家自然科学基金面上项目

基金号：82371492

资助金额:70万元

资助期限：2024.01-2027.12

3.课题名称：昼夜节律紊乱通过调节REV-ERBα/NLRP3通路加速α-突触核蛋白病进展的机制

资助单位：国家自然科学基金面上项目

基金号：82171476

资助金额:55万元

资助期限：2022-2025

4.课题名称：基于神经信息学的失眠障碍精准评估与个体化防治体系研究与应用--失眠障碍队列及多模态数字化评估平台的建设

资助单位：国家重点研发计划（子课题）

基金号：2021YFC2501500

资助金额：400万元

资助期限：2021-2024

5.课题名称：失眠障碍数字化多模态评估及认知行为治疗平台

资助单位：广州市卫健委   广州地区临床特色技术项目

资助规模：25万元

资助期限：2023-2025年

6.项目名称：基于快速眼动睡眠行为障碍建立神经变性疾病的早期精准预测和防治体系

计划编号：2023A03J0830

资助单位：广州市科技局  2023年度广州市基础研究计划市校（院）联合资助项目

投资规模：200万元

完成时间：2023-2025年

7.课题名称：Circadian rhythms dysregulation in the unaffected adolescent offspring of parents with bipolar I disorder

资助单位: Health and Medical Research Fund (HMRF)

基金号: 03140636

基金大小: 118万港币

资助期限: 2016 –2018

8.课题名称：Longitudinal course of insomnia disorder: bidirectional association with depression and roles of biomarkers

资助单位: Health and Medical Research Fund (HMRF)

基金号: 11120811

基金大小: 99.9万港币

资助期限: 2014 –2015

9.课题名称：Familial aggregation and biomarkers of REM sleep behavior disorder: a case-control family study

资助单位: Health and Medical Research Fund (HMRF)

基金号: 12131501

基金大小: 99.4万港币

资助期限: 2015 –2017

10.课题名称：昼夜节律紊乱在快速眼动睡眠行为障碍神经退行性病变进展的机制研究

资助单位: 国家自然科学基金面上项目

基金号: 81471348

基金大小: 70万人民币

资助期限: 2015 –2018

11.课题名称：Validation of Chinese Version of Structured Diagnostic Interview for Sleep Patterns and Disorders

资助单位: 香港中文大学

基金号: 2012.2.022

基金大小: 8万港币

资助期限: 2013 –2014

12.课题名称：Progression of prodromal markers of α-synucleinopathy neurodegeneration in the first-degree relatives of patients with REM sleep behavior disorder: a 5-year prospective study

资助单位: RGC General Research Fund

基金号: 24117018

基金大小: 119.8万港币

资助期限: 2018–2021

【代表性论文及著作】

1.Liang YY, Zhou M, He Y, Zhang W, Wu Q, Luo T, Zhang J, Jia F, Qi L, Ai S, Zhang J*. Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases. Nat Hum Behav. 2024 Sep 16. doi: 10.1038/s41562-024-01970-0 [IF = 21.4]

2.Liang YY, He Y, Huang P, Feng H, Li H, Ai S, Du J, Xue H, Liu Y, Zhang J, Qi L, Zhang J. Accelerometer-measured physical activity, sedentary behavior, and incidence of macrovascular and microvascular events in individuals with type 2 diabetes mellitus and prediabetes. J Sport Health Sci. 2024 Aug 29:100973. doi: 10.1016/j.jshs.2024.100973[IF = 9.7]

3.Lei B#, Feng H#, Yang L, Wang J, Chen J, Song W, Jiang C, Zhang K, Wang Q, Tsang JCC, Chan NY, Liu Y, Chan JWY, Pan J, Zhang B, Li T, Merikangas KR, Zhang J*, Wing YK*. Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder: a high-risk study in the Chinese population. Gen Psychiatr. 2024 May 22;37(3):e101239. [IF = 13.1]

4.Feng H#, Yang L#, Ai S#, Liu Y, Zhang W, Lei B, Chen J, Liu Y, Chan JWY, Chan NY, Tan X, Wang N, Benedict C, Jia F, Wing YK, Zhang J*. Association between accelerometer-measured amplitude of rest-activity rhythm and future health risk: a prospective cohort study of the UK Biobank. Lancet Healthy Longev. 2023 May;4(5):e200-e210. [IF = 13.1]

5.Jin X#, Chen Y#, Feng H, Zhou M, Chan JWY, Liu Y, Kong APS, Tan X, Wing YK, Yang L*, Zhang J*. Association of Accelerometer-measured Sleep Duration and Different Intensities of Physical Activity with Incident Type 2 Diabetes in a Population-based Cohort Study. J Sport Health Sci. 2023 Mar 3:S2095-2546(23)00021-2. [IF = 11.7]

6.Yang L#, Feng H#, Ai S#, Liu Y, Lei B, Chen J, Tan X, Benedict C, Wang N, Wing YK, Qi L*, Zhang J*. Association of accelerometer-derived circadian abnormalities and genetic risk with incidence of atrial fibrillation. NPJ Digit Med. 2023 Mar 4;6(1):31.  [IF = 15.2]

7.Liang YY, Feng H, Chen Y, Xue H, Zhou M, Ma H, Ai S, Wing YK, Geng Q*, Zhang J*. Joint Association of Physical Activity and Sleep Duration with Risk of All-cause and Cause-specific Mortality: A Population-Based Cohort Study Using Accelerometry. Eur J Prev Cardiol. 2023 Mar 29:zwad060. [IF = 8.3]

8.Feng H#, Yang L#, Liang YY#*, Ai S, Liu Y, Liu Y, Jin X, Lei B, Wang J, Zheng N, Chen X, Chan JWY, Sum RKW, Chan NY, Tan X, Benedict C, Wing YK, Zhang J*. Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study. Nat Commun. 2023 Feb 18;14(1):930. [IF = 16.6]

9.Liang YY#, Chen Y#, Feng H, Liu X, Ai QH, Xue H, Shu X, Weng F, He Z, Ma J, Ma H, Ai S, Geng Q*, Zhang J*. Association of Social Isolation and Loneliness With Incident Heart Failure in a Population-Based Cohort Study. JACC Heart Fail. 2023 Jan 20:S2213-1779(23)00026-4. [IF = 13]

10.Yang L#, Feng H#, Chen J, Wing YK, Benedict C, Tan X*, Zhang J*. Association of Circadian Rest-Activity Rhythms with Cardiovascular Disease and Mortality in Type 2 Diabetes. Diabetes Res Clin Pract. 2023 Jan 20:110262. [ IF = 5.1]

11.Feng H#, Ho AW#, Lei B, Chan JWY, Wang J, Liu Y, Tsang JCC, Chan NY, Lam SP, Merikangas KR, Ho CS, Zhang J*, Wing YK*. Dim light melatonin patterns in unaffected offspring of parents with bipolar disorder: A case-control high-risk study. J Affect Disord. 2022 Jul 22;315:42-47. [IF = 6.6]

12.Ai S#, Wang X#, Wang S, Zhao Y, Guo S, Li G, Chen Z, Lin F, Guo S, Li Y, Zhang J*, Zhao G*. Effects of glycemic traits on left ventricular structure and function: a mendelian randomization study. Cardiovasc Diabetol. 2022 Jun 17;21(1):109. [IF = 9.3]

13.Yang L#, Chen J#, Feng H, Ai S, Liu Y, Chen X, Lei B, Chan JW, Chau SWH, Tse LA, Ho AW, Ho CS, Wing YK*, Zhang J*. Night shift work, MTNR1B rs10830963 polymorphism and prostate cancer risk: Findings from a prospective, population-based study. Cancer Epidemiology Biomarkers & Prevention. 2022 Jan 21；cebp.1108.2021[IF = 3.8]

14.Ai S, Zhang J*, Zhao G, Wang N, Li G, So HC, Liu Y, Chau SW, Chen J, Tan X, Jia F, Tang X, Shi J, Lu L, Wing YK. Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank. Eur Heart J. 2021 Apr 5:ehab170.[IF = 39.3]

15.Lei B, Zhang J*, Chen S, Chen J, Yang L, Ai S, Chan NY, Wang J, Dai XJ, Feng H, Liu Y, Li SX, Jia F, Wing YK. Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort. Sleep. 2021 Feb 26:zsab053. [IF = 5.6]

16.Chen Jie, Zhang J*, So HonCheong, Ai Sizhi, Wang Ningjian, Tan Xiao*, Wing YunKwok. Association of sleep traits and heel bone mineral density: Observational and Mendelian randomization studies.[J]. Journal of bone and mineral research：the official journal of the American Society for Bone and Mineral Research,2021[IF = 6.2]

17.Feng H, Chen L, Liu Y, Chen X, Wang J, Yu MWM, Huang B, Li SX, Chau SWH, Chan JWY, Chen J, Mok VCT, Wing YK*, Zhang J*. Rest-activity Pattern Alterations in Idiopathic REM Sleep Behavior Disorder. Ann Neurol. 2020 Oct;88(4):817-829. [IF = 11.2]

18.Liu Y, Zhang J *, Lam SP, Yu MWM, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan A, Mok V, Wing YK. Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study. Sleep Med. 2019 Apr;56:128-134. .[IF = 4.8]

19.Yan R, Zhang C, Spruyt K, Wei L, Wang Z, Tian L, Li X, Ristaniemi T, Zhang J* , Cong F*. Multi-modality of polysomnography signals’ fusion for automatic sleep scoring. Biomedical Signal Processing and Control. 2019, 49 (14-23).[IF = 5.1]

20.Liu Y#, Zhang J#, Lam SP, Zhou J, Yu MWM, Li SX, Chan JWY, Postuma RB, Mok VCT, Wing YK*. A case-control-family study of idiopathic rapid eye movement sleep behavior disorder. Ann Neurol. 2019 Apr;85(4):582-592. [IF = 11.2]

21.Ding C#, Zhang J#, Lau ESH, Luk AOY, So WY, Ma RCW, Choi KC, Chan JCN, Wing YK, Kong APS. Gender differences in the associations between insomnia and glycemic control in patients with type 2 diabetes: a cross-sectional study. Sleep. 2019 Feb 4. [IF = 5.6]

22.Liu S, Wing YK, Hao Y, Li W, Zhang J*, Zhang B*. The associations of long-time mobile phone use with sleep disturbances and mental distress in technical college students: a prospective cohort study. Sleep. 2019 Feb 1;42(2).[IF = 5.6]

23.Suh S, Cho N, Zhang J*. Sex Differences in Insomnia: from Epidemiology and Etiology to Intervention. Current psychiatry reports. 2018 Aug 9;20(9):69.[IF =6.7]

24.Zhang J*, Lam SP, Li SX, Liu Y, Chan JWY, Chan MHM, Ho CS, Li AM, Wing YK. Parental history of depression and higher basal salivary cortisol in unaffected child and adolescent offspring. J Affect Disord. 2018 Jul;234:207-213. [IF = 6.6]

25.Luo C, Zhang J* , Chen W, Lu W, Pan JY*. Course, risk factors, and mental health outcomes of excessive daytime sleepiness in rural Chinese adolescents: A one-year prospective study. J Affect Disord.  2018 Apr 15;231:15-20.[IF =6.6]

26.Zhang J, Li SX, Lam SP, Wing YK*. Epidemiology of REM sleep behavior disorder: both study design and measurement tool count. Sleep Med. 2017 Dec;40:122-123. [IF =4.8]

27.Zhang J, Li SX, Lam SP, Wing YK*. REM sleep behavior disorder and obstructive sleep apnea: does one "evil" make the other less or more "evil"? Sleep Med. 2017 Sep;37:216-217.[IF =4.8]

28.Zhang J, Paksarian D, Lamers F, Hickie IB, He J, Merikangas KR*. Sleep Patterns and Mental Health Correlates in US Adolescents. J Pediatr. 2017;182:137-143. [IF =6.314]

29.Zhou J#, Zhang J#(Co-first author), Lam SP, Mok V, Chan A, Li SX, Liu Y, Tang X, Yung WH, Wing YK. Mortality and Its Risk Factors in Patients with Rapid Eye Movement Sleep Behavior Disorder. Sleep. 2016;39(8):1543-50. [IF =5.6]

30.Zhang J, Chan NY, Lam SP, Li SX, Liu Y, Chan JW, Kong AP, Ma RC, Chan KC, Li AM, Wing YK*. Emergence of Sex Differences in Insomnia Symptoms in Adolescents: A Large-Scale School-Based Study. Sleep. 2016;39(8):1563-70. [IF =5.6]

31.Zhang J, Lam SP, Kong AP, Ma RC, Li SX, Chan JW, Yu MW, Zhou J, Chan MH, Ho CS, Li AM, Tang X, Wing YK*. Family conflict and lower morning cortisol in adolescents and adults: modulation of puberty. Sci Rep. 2016;6:22531. [IF =4.6]

32.Zhang J, Lam SP, Li SX, Ma RC, Kong AP, Chan MH, Ho CS, Li AM, Wing YK*. A community-based study on the association between insomnia and hypothalamic-pituitary-adrenal axis: sex and pubertal influences. J Clin Endocrinol Metab. 2014;99(6):2277-87. [IF =5.8]

33.Zhang J, Lam SP, Li SX, Li AM, Kong AP, Wing YK*. Restless Legs Symptoms in adolescents: epidemiology, heritability, and pubertal effects. J Psychosom Res. 2014;76(2):158-64. [IF =4.7]

34.Zhang J, Lamers F, Hickie IB, He JP, Feig E, Merikangas KR*. Differentiating nonrestorative sleep from nocturnal insomnia symptoms: demographic, clinical, inflammatory, and functional correlates. Sleep. 2013;36(5):671-9. [IF =5.6]

35.Luo C, Zhang J*, Pan JY*. One-year course and impacts of insomnia in rural Chinese adolescents. Sleep. 2013;36(3):377-84. [IF =5.6]

36.Zhang J, Lam SP, Li SX, Tang NL, Yu MWM, Li AM, Wing YK. Insomnia, sleep quality, pain, and somatic symptoms: sex differences and shared genetic components. Pain. 2012 Mar;153(3):666-673.[IF =7.4]

37.Zhang J, Lam SP, Li SX, Li AM, Wing YK. The longitudinal course and impact of non-restorative sleep: a five-year community-based follow-up study. Sleep Med. 2012 Jun;13(6):570-6. [IF =4.8]

38.Wing YK, Zhang J*, Lam SP, Li SX, Tang NL, Lai KY, Li AM. Familial aggregation and heritability of insomnia in a community-based study. Sleep Med. 2012 Sep;13(8):985-90. [IF =4.8]

39.Zhang J, Lam SP, Li SX, Yu MW, Li AM, Ma RC, Kong AP, Wing YK. Long-term outcomes and predictors of chronic insomnia: a prospective study in Hong Kong Chinese adults. Sleep Med. 2012 May;13(5):455-62.[IF =4.8]

40.Pan JY*, Chou MF, Zhang J*, Liu YP. Sleep patterns, insomnia, and daytime sleepiness between Guangdong and Macau Chinese adolescents: a cross-cultural comparison study. Sleep and Biological Rhythms. 2012;43(5): 527-539.[IF =1.1]

41.Zhang J, Ma RCW , Kong APS , So WY, Li AM, Lam SP, Li SX, Yu MWM, Ho CS, Chan MHM, Zhang B, YK Wing*. Relationship of sleep quantity and quality with 24-hour urinary catecholamines and salivary awakening cortisol in healthy middle-aged adults. Sleep. 2011;34(2):225-33. [IF =5.6]

42.Zhang J, Lam SP, Li SX, Li AM, Lai KYC, Wing YK*. Longitudinal course and outcome of chronic insomnia in Hong Kong Chinese children: A 5-year follow-up study of a community-based cohort. Sleep. 2011; 34(10):1395-402.[IF =5.6]

43.Zhang J, Li AM, Fok TF, Wing YK. Roles of parental sleep/wake patterns, socioeconomic status, and daytime activities in the sleep/wake patterns of children. J Pediatr. 2010 Apr;156(4):606-12.e5. [IF =5.1]

44.Zhang J, Li AM, Kong APS, Lai KYC, Tang NLS, Wing YK*. A community-based study of insomnia in Hong Kong Chinese children- prevalence, risk factors and familial aggregation. Sleep Med. 2009; 10(9):1040-6. [IF =4.8]

45.Zhang J, Lam SP, Ho CK, Li AM, Tsoh J, Mok V, Wing YK*. Diagnosis of REM sleep behavior disorder by video-polysomnographic study: is one night enough? Sleep. 2008; 31(8):1179-85. [IF =5.6]

46.睡眠-觉醒生物节律动态解析系统V1.0.登记号：2023SR1616388，获批日期：2023年12月12日

47.多模态数字精神健康大数据管理云平台V1.0. 登记号：2023SR0574132，获批日期：2023年5月31日

48.知优眠软件（安卓版）【简称∶知优眠】V1.0 .授权号：2022SR0958721，获批日期：2022年7月22日.

49.知优眠研究版软件（安卓版）【简称∶知优眠研究版】V1.0. 授权号：2022SR0592599，获批日期：2022年5月17日.

【所获荣誉和奖励】

1.2015年荣获第6届世界睡眠医学大会（The 6th World Congress on Sleep Medicine）颁发青年科学家奖（Young investigator award）；

2.2015年荣获中国睡眠研究会睡眠障碍专业委员会颁发优秀中青年专家；

3.2016年荣获中国睡眠研究会颁发青年优秀论文奖二等奖；

4.2023年荣获荔湾区“最美科技工作者”称号。

【学术任职】

1.中国睡眠研究会青年工作委员会第三届主任委员（2022-2026）

2.中国睡眠研究会第七届理事会常务理事（2023-2027）

3.中国睡眠研究会第四届生理与药理专业委员会常务委员（2022-2026）

4.广州市医疗服务高质量发展专家库科研组成员（2023-）

5.中国医疗保健国际交流促进会睡眠医学分会常务委员（2020-2024）；

6.广东省医疗行业协会精神医学管理分会副主任委员（2020-2024）；

7.广东省医师协会精神科医师分会第五届委员会常务委员（2020-2024）；

8.广东省医学会行为医学分会第四届副主任委员（2020-2024）；

9.广东省医学会精神医学分会第十届委员（2021-2025）；

10.《Chronobiology in Medicine》副主编；

11.《中华医学杂志》通讯编委；

12.中华医学会精神医学分会CBT协作组副组长；

13.中华医学会精神医学分会社会心理服务研究协作组委员；

14.中华医学会精神医学分会睡眠障碍协作组委员。